Learn what could happen if your secondary hyperparathyroidism
is not treated
Your parathyroid glands may grow, allowing them to produce even more parathyroid hormone and make your condition worse.1
Calcium combined with phosphate may become deposited in your blood vessels and heart, making them harden1,2 and increasing your risk of heart complications,3–5 including abnormal heart rhythm,6 heart valve disease7 and heart attack.8
Your bones may become weak due to loss of calcium,9–11 increasing your risk of fractures.3,5,12
Over time, your enlarged parathyroid glands may become less sensitive to medication, making your secondary hyperparathyroidism more difficult to treat13–15 and forcing the need for your parathyroid glands to be either partially or completely removed through surgery.1
Some research even suggests that your chronic kidney disease may progress more rapidly to the stage where you need dialysis.5,16
- Cunningham J et al. Clin J Am Soc Nephrol. 2011;6:913–21.
- Castro RH et al. Poster C-1002 presented at: European Congress of Radiology (ECR) 2011; 2011 March 3–7; Vienna, Austria.
- Geng G et al. Osteoporos Int. 2019;30:2019–25.
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- Xu Y et al. Clin Kidney J. 2021;sfab006.
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- Linefsky JP et al. J Am Coll Cardiol. 2011;58(3):291–7.
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- Rix M et al. Kidney Int. 1999;56(3):1084–93.
- Qi Q et al. Am J Kidney Dis. 1995;26(4):622–31.
- Torres A et al. Kidney Int. 1995;47:1434–42.
- Yadla M et al. Saudi J Kidney Dis Transpl. 2016;27:1285–6.
- Gogusev J et al. Kidney Int. 1997;51:328–36.
- Rodriguez M et al. Am J Renal Physiol. 2005;288:F253–64.
- Fukuda N et al. J Clin Invest. 1993;92:1436–43.
- Schumock G et al. Curr Med Res Opin. 2008;24:3037–48.
- Tomasello S. Diabetes Spectr. 2008;21:19–25.
- Locatelli F et al. Nephrol Dial Transplant. 2002;17:723–31.