Learn how chronic kidney disease (CKD) causes imbalances
in your blood that lead to the development of secondary hyperparathyroidism (SHPT)1,2
Your kidneys help to control the amounts of calcium, phosphate and vitamin D hormone in your blood.1,2
When you have chronic kidney disease, your kidneys gradually become unable to maintain the right balance of these blood parameters.1,2
Too much calcium is filtered and not enough vitamin D is activated
Calcium and vitamin D hormone levels begin to drop1,2
Not enough phosphate is filtered
Phosphate level begins to rise1,2
hormone is released1,2
In order to restore balance, your parathyroid glands (four pea-sized glands located in your neck) release a hormone called parathyroid hormone (PTH).1–3
Parathyroid hormone makes your bones release calcium.2
Parathyroid hormone also makes your kidneys:2
- Remove less calcium from your blood
- Activate more vitamin D
- Remove more phosphate from your blood
In the early stages of chronic kidney disease, the parathyroid hormone works: the levels of vitamin D hormone, calcium and phosphate are brought back into balance, and your parathyroid glands reduce the amount of parathyroid hormone they release.2
However, as chronic kidney disease progresses, your parathyroid glands are forced to release increasingly abnormal amounts of parathyroid hormone. The excessive release of parathyroid hormone by your parathyroid glands due to chronic kidney disease is known as secondary hyperparathyroidism.2
- Cunningham J et al. Clin J Am Soc Nephrol. 2011;6:913–21.
- Rodriguez M et al. Am J Renal Physiol. 2005;288:F253–64.
- Chai MO et al. J Ren Nurs. 2016;8(2):74–9.
- Geng G et al. Osteoporos Int. 2019;30:2019–25.
- Xu Y et al. Clin Kidney J. 2021;sfab006.